Shubir Dutt, PhD

Postdoctoral Fellow in Neuropsychology
Fields of Interest: 
Neuropsychology
Imaging

Shubir Dutt, PhD, is a neuropsychology postdoctoral fellow at the UCSF Memory and Aging Center. He completed his PhD degree in Clinical Psychology (Major areas of study: Neuropsychology & Clinical Geropsychology) at the University of Southern California in 2023.

Shubir previously worked with the Imaging Core, Kramer Lab, and Boxer Lab from 2011–2016 before returning to the MAC in 2022 to complete his predoctoral internship and postdoctoral fellowship in Clinical Neuropsychology with Dr. Joel Kramer as part of the UCSF Clinical Psychology Training Program. Shubir’s research leverages structural/functional neuroimaging and biofluid markers to examine cerebrovascular factors impacting cognitive aging and neurodegenerative disease, as well as the role of brainstem nuclei in preclinical detection and prevention of Alzheimer’s disease.

Publications: 

Elevated vascular endothelial growth factor a is associated with disruption of default network connectivity in older adults.

Brain imaging and behavior

Kapoor A, Jang JY, Engstrom AC, Lohman T, Dutt S, Alitin JPM, Sible IJ, Marshall A, Shenasa F, Gaubert A, Nguyen A, Bradford DR, Rodgers K, Han SD, Nation DA

Association of Medial Temporal Lobe Cerebrovascular Reactivity and Memory Function in Older Adults With and Without Cognitive Impairment.

Neurology

Kapoor A, Dutt S, Engstrom AC, Alitin JPM, Lohman T, Sible IJ, Marshall A, Shenasa F, Gaubert A, Bradford DR, Sordo L, Shao X, Rodgers K, Head E, Wang DJ, Nation DA

Locus coeruleus MRI contrast, cerebral perfusion, and plasma Alzheimer's disease biomarkers in older adults.

Neurobiology of aging

Dutt S, Bachman SL, Dahl MJ, Li Y, Yew B, Jang JY, Ho JK, Nashiro K, Min J, Yoo HJ, Gaubert A, Nguyen A, Blanken AE, Sible IJ, Marshall AJ, Kapoor A, Alitin JPM, Hoang K, Rouanet J, Sordo L, Head E, Shao X, Wang DJJ, Mather M, Nation DA

Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Engstrom AC, Alitin JPM, Kapoor A, Dutt S, Lohman T, Sible IJ, Marshall AJ, Shenasa F, Gaubert A, Ferrer F, Nguyen A, Bradford DR, Rodgers K, Sordo L, Head E, Shao X, Wang DJJ, Nation DA

Cerebral perfusion and amyloidosis in the oldest-old.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Dutt S, Woodworth DC, Sajjadi SA, Greenia DE, DeCarli C, Kawas CH, Corrada MM, Nation DA

Older Adults With Smaller and Less Complex Social Networks Show Deficits in Medial Temporal Cerebrovascular Reactivity.

Journal of the American Heart Association

Chang E, Kapoor A, Lohman T, Dutt S, Alitin JPM, Sible IJ, Ho JK, Gaubert A, Blanken AE, Mather M, Shao X, Wang DJJ, Nation DA

Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.

medRxiv : the preprint server for health sciences

Engstrom AC, Alitin JP, Kapoor A, Dutt S, Lohman T, Sible IJ, Marshall AJ, Shenasa F, Gaubert A, Ferrer F, Nguyen A, Bradford DR, Rodgers K, Sordo L, Head E, Shao X, Wang DJ, Nation DA

The interactive effect of intra-beat and inter-beat blood pressure variability on neurodegeneration in older adults.

medRxiv : the preprint server for health sciences

Lohman T, Shenasa F, Sible I, Kapoor A, Engstrom AC, Dutt S, Head E, Sordo L, M Alitin JP, Gaubert A, Nguyen A, Nation DA

Older adults with reduced cerebrovascular reactivity exhibit high white matter hyperintensity burden.

Neurobiology of aging

Kapoor A, Dutt S, Alitin JPM, Sible IJ, Marshall A, Shenasa F, Engstrom AC, Gaubert A, Shao X, Bradford DR, Rodgers K, Mather M, Wang DJJ, Nation DA

Short-term blood pressure variability and brain functional network connectivity in older adults.

Neuroimage. Reports

Sible IJ, Jang JY, Blanken AE, Alitin JPM, Engstrom A, Dutt S, Marshall AJ, Kapoor A, Shenasa F, Gaubert A, Nguyen A, Ferrer F, Bradford DR, Rodgers KE, Mather M, Duke Han S, Nation DA

Daily biofeedback to modulate heart rate oscillations affects structural volume in hippocampal subregions targeted by the locus coeruleus in older adults but not younger adults.

medRxiv : the preprint server for health sciences

Yoo HJ, Nashiro K, Dutt S, Min J, Cho C, Thayer JF, Lehrer P, Chang C, Mather M

The integrity of dopaminergic and noradrenergic brain regions is associated with different aspects of late-life memory performance.

Nature aging

Dahl MJ, Bachman SL, Dutt S, Düzel S, Bodammer NC, Lindenberger U, Kühn S, Werkle-Bergner M, Mather M

Multimodal neuroimaging data from a 5-week heart rate variability biofeedback randomized clinical trial.

Scientific data

Yoo HJ, Nashiro K, Min J, Cho C, Mercer N, Bachman SL, Nasseri P, Dutt S, Porat S, Choi P, Zhang Y, Grigoryan V, Feng T, Thayer JF, Lehrer P, Chang C, Stanley JA, Head E, Rouanet J, Marmarelis VZ, Narayanan S, Wisnowski J, Nation DA, Mather M

Enlarged perivascular spaces and plasma Aβ42/Aβ40 ratio in older adults without dementia.

Neurobiology of aging

Kapoor A, Gaubert A, Yew B, Jang JY, Dutt S, Li Y, Alitin JPM, Nguyen A, Ho JK, Blanken AE, Sible IJ, Marshall A, Shenasa F, Rodgers KE, Martini AC, Head E, Nation DA

Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Ehrenberg AJ, Kelberman MA, Liu KY, Dahl MJ, Weinshenker D, Falgàs N, Dutt S, Mather M, Ludwig M, Betts MJ, Winer JR, Teipel S, Weigand AJ, Eschenko O, Hämmerer D, Leiman M, Counts SE, Shine JM, Robertson IH, Levey AI, Lancini E, Son G, Schneider C, Egroo MV, Liguori C, Wang Q, Vazey EM, Rodriguez-Porcel F, Haag L, Bondi MW, Vanneste S, Freeze WM, Yi YJ, Maldinov M, Gatchel J, Satpati A, Babiloni C, Kremen WS, Howard R, Jacobs HIL, Grinberg LT

Blood-Derived Progenitor Cells Are Depleted in Older Adults with Cognitive Impairment: A Role for Vascular Resilience?

Journal of Alzheimer's disease : JAD

Marshall AJ, Gaubert A, Kapoor A, Tan A, McIntosh E, Jang JY, Yew B, Ho JK, Blanken AE, Dutt S, Sible IJ, Li Y, Rodgers K, Nation DA

Older Adults With Higher Blood Pressure Variability Exhibit Cerebrovascular Reactivity Deficits.

American journal of hypertension

Sible IJ, Jang JY, Dutt S, Yew B, Alitin JPM, Li Y, Blanken AE, Ho JK, Marshall AJ, Kapoor A, Shenasa F, Gaubert A, Nguyen A, Sturm VE, Mather M, Rodgers KE, Shao X, Wang DJ, Nation DA

Older adults with perivascular spaces exhibit cerebrovascular reactivity deficits.

NeuroImage

Kapoor A, Yew B, Jang JY, Dutt S, Li Y, Alitin JPM, Gaubert A, Ho JK, Blanken AE, Sible IJ, Marshall A, Shao X, Mather M, Wang DJJ, Nation DA

Blood pressure variability and plasma Alzheimer's disease biomarkers in older adults.

Scientific reports

Sible IJ, Yew B, Jang JY, Alitin JPM, Li Y, Gaubert A, Nguyen A, Dutt S, Blanken AE, Ho JK, Marshall AJ, Kapoor A, Shenasa F, Rodgers KE, Sturm VE, Head E, Martini A, Nation DA

Increasing coordination and responsivity of emotion-related brain regions with a heart rate variability biofeedback randomized trial.

Cognitive, affective & behavioral neuroscience

Nashiro K, Min J, Yoo HJ, Cho C, Bachman SL, Dutt S, Thayer JF, Lehrer PM, Feng T, Mercer N, Nasseri P, Wang D, Chang C, Marmarelis VZ, Narayanan S, Nation DA, Mather M

Heart rate variability (HRV) changes and cortical volume changes in a randomized trial of five weeks of daily HRV biofeedback in younger and older adults.

International journal of psychophysiology : official journal of the International Organization of Psychophysiology

Yoo HJ, Nashiro K, Min J, Cho C, Bachman SL, Nasseri P, Porat S, Dutt S, Grigoryan V, Choi P, Thayer JF, Lehrer PM, Chang C, Mather M

Cerebrovascular reactivity deficits in cognitively unimpaired older adults: vasodilatory versus vasoconstrictive responses.

Neurobiology of aging

Yew B, Jang JY, Dutt S, Li Y, Sible IJ, Gaubert A, Ho JK, Blanken AE, Marshall A, Shao X, Wang DJJ, Nation DA

Selective vulnerability of medial temporal regions to short-term blood pressure variability and cerebral hypoperfusion in older adults.

Neuroimage. Reports

Sible IJ, Yew B, Dutt S, Li Y, Blanken AE, Jang JY, Ho JK, Marshall AJ, Kapoor A, Gaubert A, Bangen KJ, Sturm VE, Shao X, Wang DJ, Nation DA

Increased Levels of Circulating Angiogenic Cells and Signaling Proteins in Older Adults With Cerebral Small Vessel Disease.

Frontiers in aging neuroscience

Kapoor A, Gaubert A, Marshall A, Meier IB, Yew B, Ho JK, Blanken AE, Dutt S, Sible IJ, Li Y, Jang JY, Brickman AM, Rodgers K, Nation DA

Resting-State Functional Connectivity Signatures of Apathy in Community-Living Older Adults.

Frontiers in aging neuroscience

Jang JY, Han SD, Yew B, Blanken AE, Dutt S, Li Y, Ho JK, Gaubert A, Nation DA

Visit-to-visit blood pressure variability and regional cerebral perfusion decline in older adults.

Neurobiology of aging

Sible IJ, Yew B, Dutt S, Bangen KJ, Li Y, Nation DA, Alzheimer's Disease Neuroimaging Initiative

Brainstem substructures and cognition in prodromal Alzheimer's disease.

Brain imaging and behavior

Dutt S, Li Y, Mather M, Nation DA, Alzheimer’s Disease Neuroimaging Initiative

Affective Neuropsychiatric Symptoms as Early Signs of Dementia Risk in Older Adults.

Journal of Alzheimer's disease : JAD

Jang JY, Ho JK, Blanken AE, Dutt S, Nation DA, Alzheimer’s Disease Neuroimaging Initiative

Brainstem Volumetric Integrity in Preclinical and Prodromal Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Dutt S, Li Y, Mather M, Nation DA, Alzheimer’s Disease Neuroimaging Initiative

Disentangling Heterogeneity in Alzheimer's Disease: Two Empirically-Derived Subtypes.

Journal of Alzheimer's disease : JAD

Blanken AE, Dutt S, Li Y, Nation DA, Alzheimer’s Disease Neuroimaging Initiative

Neuropsychological Decline Improves Prediction of Dementia Beyond Alzheimer's Disease Biomarker and Mild Cognitive Impairment Diagnoses.

Journal of Alzheimer's disease : JAD

Nation DA, Ho JK, Dutt S, Han SD, Lai MHC, Alzheimer’s Disease Neuroimaging Initiative

Circulating Progenitor Cells Correlate with Memory, Posterior Cortical Thickness, and Hippocampal Perfusion.

Journal of Alzheimer's disease : JAD

Nation DA, Tan A, Dutt S, McIntosh EC, Yew B, Ho JK, Blanken AE, Jang JY, Rodgers KE, Gaubert A

Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults.

Neurobiology of aging

Casaletto KB, Ward ME, Baker NS, Bettcher BM, Gelfand JM, Li Y, Chen R, Dutt S, Miller B, Kramer JH, Green AJ

Progression of brain atrophy in PSP and CBS over 6 months and 1 year.

Neurology

Dutt S, Binney RJ, Heuer HW, Luong P, Attygalle S, Bhatt P, Marx GA, Elofson J, Tartaglia MC, Litvan I, McGinnis SM, Dickerson BC, Kornak J, Waltzman D, Voltarelli L, Schuff N, Rabinovici GD, Kramer JH, Jack CR, Miller BL, Rosen HJ, Boxer AL

Comparing Volume Loss in Neuroanatomical Regions of Emotion versus Regions of Cognition in Healthy Aging.

PloS one

Pressman PS, Noniyeva Y, Bott N, Dutt S, Sturm V, Miller BL, Kramer JH

Progression of Microstructural Degeneration in Progressive Supranuclear Palsy and Corticobasal Syndrome: A Longitudinal Diffusion Tensor Imaging Study.

PloS one

Zhang Y, Walter R, Ng P, Luong PN, Dutt S, Heuer H, Rojas-Rodriguez JC, Tsai R, Litvan I, Dickerson BC, Tartaglia MC, Rabinovici G, Miller BL, Rosen HJ, Schuff N, Boxer AL

Neuroanatomical substrates of executive functions: Beyond prefrontal structures.

Neuropsychologia

Bettcher BM, Mungas D, Patel N, Elofson J, Dutt S, Wynn M, Watson CL, Stephens M, Walsh CM, Kramer JH

Relationship between Insulin-Resistance Processing Speed and Specific Executive Function Profiles in Neurologically Intact Older Adults.

Journal of the International Neuropsychological Society : JINS

Frazier DT, Bettcher BM, Dutt S, Patel N, Mungas D, Miller J, Green R, Kramer JH

Memory profiles in pathology or biomarker confirmed Alzheimer disease and frontotemporal dementia.

Alzheimer disease and associated disorders

Mansoor Y, Jastrzab L, Dutt S, Miller BL, Seeley WW, Kramer JH

Bayesian segmentation of brainstem structures in MRI.

NeuroImage

Iglesias JE, Van Leemput K, Bhatt P, Casillas C, Dutt S, Schuff N, Truran-Sacrey D, Boxer A, Fischl B, Alzheimer's Disease Neuroimaging Initiative

The Chinese Verbal Learning Test specifically assesses hippocampal state.

American journal of Alzheimer's disease and other dementias

Tsai RM, Leong JK, Dutt S, Chang CC, Lee AK, Chao SZ, Yokoyama JS, Tse M, Kramer JH, Miller BL, Rosen HJ

Interleukin-6, age, and corpus callosum integrity.

PloS one

Bettcher BM, Watson CL, Walsh CM, Lobach IV, Neuhaus J, Miller JW, Green R, Patel N, Dutt S, Busovaca E, Rosen HJ, Yaffe K, Miller BL, Kramer JH

The functional oculomotor network and saccadic cognitive control in healthy elders.

NeuroImage

Pa J, Dutt S, Mirsky JB, Heuer HW, Keselman P, Kong E, Trujillo A, Gazzaley A, Kramer JH, Seeley WW, Miller BL, Boxer AL