Stephanie Gaus, PhD

Research Scientist
[email protected]
+1 415 502-7194
Fields of Interest: 
Pathology

Stephanie joined the Seeley Selective Vulnerability Research Laboratory in October 2007 as an Associate Specialist. Her background is in sleep and circadian rhythms research, including neuroanatomy. She completed a doctorate in neurobiology (CB Saper, Harvard University), a master's in medical science (Harvard Medical School), and a postdoc focusing on narcolepsy (E Mignot, Stanford University/Howard Hughes Medical Institute). In the Seeley lab, Stephanie is helping to characterize von Economo neurons in health and disease. Using immunohistochemical and molecular biological techniques, Stephanie is exploring the normal and pathological neuroanatomy and pathology of these neurons.

Publications: 

Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics.

bioRxiv : the preprint server for biology

Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, Vinters H, Trojanowski JQ, Seeley WW, Malhotra D, Geschwind DH

Tuberous sclerosis complex is associated with a novel human tauopathy.

Acta neuropathologica

Hwang JL, Perloff OS, Gaus SE, Benitez C, Alquezar C, Cosme CQ, Nana AL, Vatsavayai SC, Ramos EM, Geschwind DH, Miller BL, Kao AW, Seeley WW

Salience Network Atrophy Links Neuron Type-Specific Pathobiology to Loss of Empathy in Frontotemporal Dementia.

Cerebral cortex (New York, N.Y. : 1991)

Pasquini L, Nana AL, Toller G, Brown JA, Deng J, Staffaroni A, Kim EJ, Hwang JL, Li L, Park Y, Gaus SE, Allen I, Sturm VE, Spina S, Grinberg LT, Rankin KP, Kramer JH, Rosen HJ, Miller BL, Seeley WW

Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy.

JAMA neurology

Mantyh WG, Spina S, Lee A, Iaccarino L, Soleimani-Meigooni D, Tsoy E, Mellinger TJ, Grant H, Vandevrede L, La Joie R, Lesman-Segev O, Gaus S, Possin KL, Grinberg LT, Miller BL, Seeley WW, Rabinovici GD

Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants.

Acta neuropathologica communications

Lin LC, Nana AL, Hepker M, Hwang JL, Gaus SE, Spina S, Cosme CG, Gan L, Grinberg LT, Geschwind DH, Coppola G, Rosen HJ, Miller BL, Seeley WW

Evidence of corticofugal tau spreading in patients with frontotemporal dementia.

Acta neuropathologica

Kim EJ, Hwang JL, Gaus SE, Nana AL, Deng J, Brown JA, Spina S, Lee MJ, Ramos EM, Grinberg LT, Kramer JH, Boxer AL, Gorno-Tempini ML, Rosen HJ, Miller BL, Seeley WW

Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies.

Brain : a journal of neurology

Spina S, Brown JA, Deng J, Gardner RC, Nana AL, Hwang JL, Gaus SE, Huang EJ, Kramer JH, Rosen HJ, Kornak J, Neuhaus J, Miller BL, Grinberg LT, Boxer AL, Seeley WW

Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology.

Acta neuropathologica

Nana AL, Sidhu M, Gaus SE, Hwang JL, Li L, Park Y, Kim EJ, Pasquini L, Allen IE, Rankin KP, Toller G, Kramer JH, Geschwind DH, Coppola G, Huang EJ, Grinberg LT, Miller BL, Seeley WW

Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration.

Neurology

Seo SW, Thibodeau MP, Perry DC, Hua A, Sidhu M, Sible I, Vargas JNS, Gaus SE, Rabinovici GD, Rankin KD, Boxer AL, Kramer JH, Rosen HJ, Gorno-Tempini ML, Grinberg LT, Huang EJ, DeArmond SJ, Trojanowski JQ, Miller BL, Seeley WW

Von Economo Neurons and Fork Cells: A Neurochemical Signature Linked to Monoaminergic Function.

Cerebral cortex (New York, N.Y. : 1991)

Dijkstra AA, Lin LC, Nana AL, Gaus SE, Seeley WW

Clinicopathological correlations in behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW

Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia.

Brain : a journal of neurology

Vatsavayai SC, Yoon SJ, Gardner RC, Gendron TF, Vargas JN, Trujillo A, Pribadi M, Phillips JJ, Gaus SE, Hixson JD, Garcia PA, Rabinovici GD, Coppola G, Geschwind DH, Petrucelli L, Miller BL, Seeley WW

Selective Frontoinsular von Economo Neuron and Fork Cell Loss in Early Behavioral Variant Frontotemporal Dementia.

Cerebral cortex (New York, N.Y. : 1991)

Kim EJ, Sidhu M, Gaus SE, Huang EJ, Hof PR, Miller BL, DeArmond SJ, Seeley WW

Distinctive neurons of the anterior cingulate and frontoinsular cortex: a historical perspective.

Cerebral cortex (New York, N.Y. : 1991)

Seeley WW, Merkle FT, Gaus SE, Craig AD, Allman JM, Hof PR, Economo CV

Selective frontoinsular von Economo neuron and fork cell loss in early behavioral variant frontotemporal dementia.

Cerebral cortex (New York, N.Y. : 1991)

Kim EJ, Sidhu M, Gaus SE, Huang EJ, Hof PR, Miller BL, DeArmond SJ, Seeley WW

IGFBP3 colocalizes with and regulates hypocretin (orexin).

PloS one

Honda M, Eriksson KS, Zhang S, Tanaka S, Lin L, Salehi A, Hesla PE, Maehlen J, Gaus SE, Yanagisawa M, Sakurai T, Taheri S, Tsuchiya K, Honda Y, Mignot E

Regulation of hypocretin (orexin) expression in embryonic zebrafish.

The Journal of biological chemistry

Faraco JH, Appelbaum L, Marin W, Gaus SE, Mourrain P, Mignot E

Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J

Selective activation of the extended ventrolateral preoptic nucleus during rapid eye movement sleep.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Lu J, Bjorkum AA, Xu M, Gaus SE, Shiromani PJ, Saper CB