Creation of Stem Cells from Patients with FTD

Purpose of the Study

The purpose of this research-oriented study is to learn more about the underlying basis of frontotemporal dementia (FTD) and related neurodegenerative disorders. We will obtain human skin cells from patients with FTD or a related disorder, unaffected family members and healthy volunteers. From these skin cells, we will make other cells called induced pluripotent stem cells (iPSCs) that can be used to produce cell lines for further basic research studies.

Eligibility

Inclusion Criteria: Participants must a) have a diagnosis of frontotemporal dementia (FTD) or one of the related disorders, semantic dementia, progressive nonfluent aphasia, progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), Alzheimer’s disease (AD), Creutzfeldt Jakob disease (CJD); b) be a healthy relative of a person with a diagnosis of neurodegenerative disease; or c) be other healthy control.

Exclusion Criteria: Subjects carrying infectious diseases (e.g., HIV, HCV, HBV, syphilis) will be excluded for laboratory safety reasons. Subjects with known wound-healing problems will be excluded.

What to Expect

Testing: A skin biopsy, taken usually from the upper thigh, and a blood draw to allow for HIV, hepatitis B and C, and syphilis testing

The Frequency of Visits: One visit

Materials Needed Before Evaluation: None

Costs: No costs will be charged for any of the study procedures. Participants are responsible for covering their traveling and accommodation expenses.

Contact information

If you are interested in participating in this study or have any questions, please contact the Genetics and Biospecimens Program Manager, Argentina Lario Lago, PhD, at [email protected] or 415.502.3773.