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Greg received his bachelor's degree in Microbiology from Brigham Young University where he developed a new class of influenza inhibitors. He completed his PhD degree at UCSF in Martin Kampmann's Lab. In the Kampmann lab, he studied how the V337M tau mutation perturbs differentiating iPSC-derived neurons. Greg works with the Clelland Lab at the Memory and Aging Center to develop new methods for screening nanoparticle delivery of gene editing therapies.
San-Hae is a postdoctoral researcher at the UCSF Memory and Aging Center under the mentorship of Dr. Claire Clelland. His research focuses on developing delivery systems for CRISPR-based therapies to treat neurodegenerative diseases.
Tanya grew up in Brooklyn, New York. She studied Molecular and Cell Biology with an emphasis on Neurobiology and Computer Science at UC Berkeley. As an undergraduate, she joined the Dipoppa Lab where she created computational simulations of the desynchronization of excitatory neuron firing, a phenomenon observed during development. Her research also focused on the absence of this synchronization, which has implications in Fragile X. She also worked in the Harland Lab, where she modeled the decentralized nervous system of the jellyfish Cassiopea.
The Clelland laboratory aims to develop cures for dementia and related neurodegenerative diseases. She is focused on monogenic causes of frontotemporal dementia and amyotrophic lateral sclerosis, such as mutations in the C9orf72 gene. She and her team develop CRISPR gene editing approaches in relevant cell types derived from human iPSCs and are working to develop better cell model systems of disease.
