Howie Rosen, MD

Professor
Neurology
+1 415 476-5567

Dr. Rosen is a behavioral neurologist. He received his medical degree from Boston University School of Medicine, trained in internal medicine at the Albert Einstein College of Medicine in New York, and subsequently completed a neurology residency at UCSF. After residency, Dr. Rosen pursued fellowship training in brain imaging at the Washington University School of Medicine, and then returned to UCSF to join the team at the Memory and Aging Center (MAC) in 1999.

Dr. Rosen’s primary research interest is in the effects that atypical neurodegenerative diseases, in particular frontotemporal dementia, have on the brain, especially the emotional systems. His current projects use psychophysiology and imaging to examine how these diseases affect self-awareness, and to determine how imaging and other biological markers can be used to track and to anticipate how these disease affect the brain over time. He is also director of education and outreach for the education core in UCSF’s Alzheimer’s Disease Research Center.

As part of the MAC and the UCSF Department of Neurology, he participates in the training of medical students, residents and fellows, and participates in the evaluation of new patients in the MAC clinic as well as the continued management of care for some of these individuals in the continuity clinic.

Publications: 

The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Staffaroni AM, Brown JA, Casaletto KB, Elahi FM, Deng J, Neuhaus J, Cobigo Y, Mumford PS, Walters S, Saloner R, Karydas A, Coppola G, Rosen HJ, Miller BL, Seeley WW, Kramer JH

Downregulation of exosomal miR-204-5p and miR-632 as a biomarker for FTD: a GENFI study.

Journal of neurology, neurosurgery, and psychiatry

Schneider R, McKeever P, Kim T, Graff C, van Swieten JC, Karydas A, Boxer A, Rosen H, Miller BL, Laforce R, Galimberti D, Masellis M, Borroni B, Zhang Z, Zinman L, Rohrer JD, Tartaglia MC, Robertson J

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies.

PLoS medicine

Broce I, Karch CM, Wen N, Fan CC, Wang Y, Tan CH, Kouri N, Ross OA, Höglinger GU, Muller U, Hardy J

Neuroimaging in Dementia.

Seminars in neurology

Staffaroni AM, Elahi FM, McDermott D, Marton K, Karageorgiou E, Sacco S, Paoletti M, Caverzasi E, Hess CP, Rosen HJ, Geschwind MD

Clinicopathological correlations in behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW

Reward deficits in behavioural variant frontotemporal dementia include insensitivity to negative stimuli.

Brain : a journal of neurology

Perry DC, Datta S, Sturm VE, Wood KA, Zakrzewski J, Seeley WW, Miller BL, Kramer JH, Rosen HJ

Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease.

Brain : a journal of neurology

Bejanin A, Schonhaut DR, La Joie R, Kramer JH, Baker SL, Sosa N, Ayakta N, Cantwell A, Janabi M, Lauriola M, O'Neil JP, Gorno-Tempini ML, Miller ZA, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD

Progressive Brain Atrophy Despite Persistent Viral Suppression in HIV Patients Older Than 60 Years.

Journal of acquired immune deficiency syndromes (1999)

Clifford KM, Samboju V, Cobigo Y, Milanini B, Marx GA, Hellmuth JM, Rosen HJ, Kramer JH, Allen IE, Valcour VG

Alzheimer disease brain atrophy subtypes are associated with cognition and rate of decline.

Neurology

Risacher SL, Anderson WH, Charil A, Castelluccio PF, Shcherbinin S, Saykin AJ, Schwarz AJ

In vivo staging of regional amyloid deposition.

Neurology

Grothe MJ, Barthel H, Sepulcre J, Dyrba M, Sabri O, Teipel SJ

Mistakes, Too Few to Mention? Impaired Self-conscious Emotional Processing of Errors in the Behavioral Variant of Frontotemporal Dementia.

Frontiers in behavioral neuroscience

Scherling CS, Zakrzewski J, Datta S, Levenson RW, Shimamura AP, Sturm VE, Miller BL, Rosen HJ

Visuospatial Functioning in the Primary Progressive Aphasias.

Journal of the International Neuropsychological Society : JINS

Watson CL, Possin K, Allen IE, Hubbard HI, Meyer M, Welch AE, Rabinovici GD, Rosen H, Rankin KP, Miller Z, Santos-Santos MA, Kramer JH, Miller BL, Gorno-Tempini ML

Local and distant relationships between amyloid, tau and neurodegeneration in Alzheimer's Disease.

NeuroImage. Clinical

Iaccarino L, Tammewar G, Ayakta N, Baker SL, Bejanin A, Boxer AL, Gorno-Tempini ML, Janabi M, Kramer JH, Lazaris A, Lockhart SN, Miller BL, Miller ZA, O'Neil JP, Ossenkoppele R, Rosen HJ, Schonhaut DR, Jagust WJ, Rabinovici GD

Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.

NeuroImage. Clinical

Elahi FM, Marx G, Cobigo Y, Staffaroni AM, Kornak J, Tosun D, Boxer AL, Kramer JH, Miller BL, Rosen HJ

Prosocial deficits in behavioral variant frontotemporal dementia relate to reward network atrophy.

Brain and behavior

Sturm VE, Perry DC, Wood K, Hua AY, Alcantar O, Datta S, Rankin KP, Rosen HJ, Miller BL, Kramer JH

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.

Nature genetics

Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Longstreth WT, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J

Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration.

Brain and behavior

Binney RJ, Pankov A, Marx G, He X, McKenna F, Staffaroni AM, Kornak J, Attygalle S, Boxer AL, Schuff N, Gorno-Tempini ML, Weiner MW, Kramer JH, Miller BL, Rosen HJ

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score.

PLoS medicine

Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM

Typical and atypical pathology in primary progressive aphasia variants.

Annals of neurology

Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, Miller BL, Seeley WW, Gorno-Tempini ML

Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia.

Acta neuropathologica

Yokoyama JS, Karch CM, Fan CC, Bonham LW, Kouri N, Ross OA, Rademakers R, Kim J, Wang Y, Höglinger GU, Müller U, Ferrari R, Hardy J

Transethnic genome-wide scan identifies novel Alzheimer's disease loci.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JSK, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR

Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease.

Neurocase

Bonham LW, Sirkis DW, Fan J, Aparicio RE, Tse M, Ramos EM, Wang Q, Coppola G, Rosen HJ, Miller BL, Yokoyama JS

Frontotemporal dementia with the V337M MAPT mutation: Tau-PET and pathology correlations.

Neurology

Spina S, Schonhaut DR, Boeve BF, Seeley WW, Ossenkoppele R, O'Neil JP, Lazaris A, Rosen HJ, Boxer AL, Perry DC, Miller BL, Dickson DW, Parisi JE, Jagust WJ, Murray ME, Rabinovici GD

Genome-wide association study identifies MAPT locus influencing human plasma tau levels.

Neurology

Chen J, Yu JT, Wojta K, Wang HF, Zetterberg H, Blennow K, Yokoyama JS, Weiner MW, Kramer JH, Rosen H, Miller BL, Coppola G, Boxer AL

Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load.

Neurology

Grothe MJ, Villeneuve S, Dyrba M, Bartrés-Faz D, Wirth M

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers.

NeuroImage. Clinical

Lee SE, Sias AC, Mandelli ML, Brown JA, Brown AB, Khazenzon AM, Vidovszky AA, Zanto TP, Karydas AM, Pribadi M, Dokuru D, Coppola G, Geschwind DH, Rademakers R, Gorno-Tempini ML, Rosen HJ, Miller BL, Seeley WW

Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases.

Journal of neurology, neurosurgery, and psychiatry

Ferrari R, Wang Y, Vandrovcova J, Guelfi S, Witeolar A, Karch CM, Schork AJ, Fan CC, Brewer JB

Regional correlations between [11C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort.

NeuroImage. Clinical

Seo SW, Ayakta N, Grinberg LT, Villeneuve S, Lehmann M, Reed B, DeCarli C, Miller BL, Rosen HJ, Boxer AL, O'Neil JP, Jin LW, Seeley WW, Jagust WJ, Rabinovici GD

Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture.

Neurology(R) neuroimmunology & neuroinflammation

Miller ZA, Sturm VE, Camsari GB, Karydas A, Yokoyama JS, Grinberg LT, Boxer AL, Rosen HJ, Rankin KP, Gorno-Tempini ML, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Graff-Radford NR, Miller BL

Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America

Zhang X, Mormino EC, Sun N, Sperling RA, Sabuncu MR, Yeo BT

Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage.

Neurology

Bertoux M, Sarazin M, Pasquier F, Bottlaender M, de Souza LC, Mioshi E, Hornberger M, Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, You SC, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL

Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration.

JAMA neurology

Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL

Diagnostic utility of ASL-MRI and FDG-PET in the behavioral variant of FTD and AD.

Annals of clinical and translational neurology

Tosun D, Schuff N, Rabinovici GD, Ayakta N, Miller BL, Jagust W, Kramer J, Weiner MM, Rosen HJ

Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia.

Brain : a journal of neurology

Mandelli ML, Vilaplana E, Brown JA, Hubbard HI, Binney RJ, Attygalle S, Santos-Santos MA, Miller ZA, Pakvasa M, Henry ML, Rosen HJ, Henry RG, Rabinovici GD, Miller BL, Seeley WW, Gorno-Tempini ML

Polygenic risk of Alzheimer disease is associated with early- and late-life processes.

Neurology

Mormino EC, Sperling RA, Holmes AJ, Buckner RL, De Jager PL, Smoller JW, Sabuncu MR

Decreased Self-Appraisal Accuracy on Cognitive Tests of Executive Functioning Is a Predictor of Decline in Mild Cognitive Impairment.

Frontiers in aging neuroscience

Scherling CS, Wilkins SE, Zakrezewski J, Kramer JH, Miller BL, Weiner MW, Rosen HJ

Reading words and other people: A comparison of exception word, familiar face and affect processing in the left and right temporal variants of primary progressive aphasia.

Cortex; a journal devoted to the study of the nervous system and behavior

Binney RJ, Henry ML, Babiak M, Pressman PS, Santos-Santos MA, Narvid J, Mandelli ML, Strain PJ, Miller BL, Rankin KP, Rosen HJ, Gorno-Tempini ML

Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease.

JAMA neurology

Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, Hess CP, Miller Z, Bonham LW, Shen J, Rabinovici GD, Rosen HJ, Miller BL, Hyman BT, Schellenberg GD, Karlsen TH, Andreassen OA, Dale AM, Desikan RS

Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration.

JAMA neurology

Santos-Santos MA, Mandelli ML, Binney RJ, Ogar J, Wilson SM, Henry ML, Hubbard HI, Meese M, Attygalle S, Rosenberg L, Pakvasa M, Trojanowski JQ, Grinberg LT, Rosen H, Boxer AL, Miller BL, Seeley WW, Gorno-Tempini ML

The impact of PICALM genetic variations on reserve capacity of posterior cingulate in AD continuum.

Scientific reports

Xu W, Wang HF, Tan L, Tan MS, Tan CC, Zhu XC, Miao D, Yu WJ, Jiang T, Tan L, Yu JT

Dominant hemisphere lateralization of cortical parasympathetic control as revealed by frontotemporal dementia.

Proceedings of the National Academy of Sciences of the United States of America

Guo CC, Sturm VE, Zhou J, Gennatas ED, Trujillo AJ, Hua AY, Crawford R, Stables L, Kramer JH, Rankin K, Levenson RW, Rosen HJ, Miller BL, Seeley WW

Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy.

Neurology

Sundermann EE, Biegon A, Rubin LH, Lipton RB, Mowrey W, Landau S, Maki PM

Assessment of the genetic variance of late-onset Alzheimer's disease.

Neurobiology of aging

Ridge PG, Hoyt KB, Boehme K, Mukherjee S, Crane PK, Haines JL, Mayeux R, Farrer LA, Pericak-Vance MA, Schellenberg GD, Kauwe JSK

Cognition and neuropsychiatry in behavioral variant frontotemporal dementia by disease stage.

Neurology

Ranasinghe KG, Rankin KP, Lobach IV, Kramer JH, Sturm VE, Bettcher BM, Possin K, Christine You S, Lamarre AK, Shany-Ur T, Stephens ML, Perry DC, Lee SE, Miller ZA, Gorno-Tempini ML, Rosen HJ, Boxer A, Seeley WW, Rabinovici GD, Vossel KA, Miller BL

The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.

Neurobiology of aging

Lupton MK, Strike L, Hansell NK, Wen W, Mather KA, Armstrong NJ, Thalamuthu A, McMahon KL, de Zubicaray GI, Assareh AA, Simmons A, Proitsi P, Powell JF, Montgomery GW, Hibar DP, Westman E, Tsolaki M, Kloszewska I, Soininen H, Mecocci P, Velas B, Lovestone S

Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression.

JAMA neurology

Zetterberg H, Skillbäck T, Mattsson N, Trojanowski JQ, Portelius E, Shaw LM, Weiner MW, Blennow K

Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals.

JAMA neurology

Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith PA, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Lee JH, Schellenberg GD, St George-Hyslop P, Mayeux R, Rogaeva E

Cortical Amyloid ß Deposition and Current Depressive Symptoms in Alzheimer Disease and Mild Cognitive Impairment.

Journal of geriatric psychiatry and neurology

Chung JK, Plitman E, Nakajima S, Chakravarty MM, Caravaggio F, Gerretsen P, Iwata Y, Graff-Guerrero A

Data-driven regions of interest for longitudinal change in frontotemporal lobar degeneration.

NeuroImage. Clinical

Pankov A, Binney RJ, Staffaroni AM, Kornak J, Attygalle S, Schuff N, Weiner MW, Kramer JH, Dickerson BC, Miller BL, Rosen HJ

Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease.

Human brain mapping

Ossenkoppele R, Cohn-Sheehy BI, La Joie R, Vogel JW, Möller C, Lehmann M, van Berckel BN, Seeley WW, Pijnenburg YA, Gorno-Tempini ML, Kramer JH, Barkhof F, Rosen HJ, van der Flier WM, Jagust WJ, Miller BL, Scheltens P, Rabinovici GD

CFH Variants Affect Structural and Functional Brain Changes and Genetic Risk of Alzheimer's Disease.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Zhang DF, Li J, Wu H, Cui Y, Bi R, Zhou HJ, Wang HZ, Zhang C, Wang D

Cerebral Microbleeds, CSF p-Tau, and Cognitive Decline: Significance of Anatomic Distribution.

AJNR. American journal of neuroradiology

Chiang GC, Cruz Hernandez JC, Kantarci K, Jack CR, Weiner MW

Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects.

Brain : a journal of neurology

Toledo JB, Zetterberg H, van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, Moghekar A, Albert M, Hu WT, Monge Argilés JA, Gorostidi A, Teunissen CE, De Deyn PP, Hyman BT, Molinuevo JL, Frisoni GB, Linazasoro G, de Leon MJ, van der Flier WM, Scheltens P, Blennow K, Shaw LM, Trojanowski JQ

Estimating anatomical trajectories with Bayesian mixed-effects modeling.

NeuroImage

Ziegler G, Penny WD, Ridgway GR, Ourselin S, Friston KJ

Associations between Verbal Learning Slope and Neuroimaging Markers across the Cognitive Aging Spectrum.

Journal of the International Neuropsychological Society : JINS

Gifford KA, Phillips JS, Samuels LR, Lane EM, Bell SP, Liu D, Hohman TJ, Romano RR, Fritzsche LR, Lu Z, Jefferson AL

Longitudinal Partial Volume Correction in 2-[18F]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Studies of Alzheimer Disease.

Journal of computer assisted tomography

Malpas CB, Saling MM, Velakoulis D, Desmond P, Hicks RJ, O'Brien TJ

Frontotemporal Dementia and Psychiatric Illness: Emerging Clinical and Biological Links in Gene Carriers.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Block NR, Sha SJ, Karydas AM, Fong JC, De May MG, Miller BL, Rosen HJ

Applying Automated MR-Based Diagnostic Methods to the Memory Clinic: A Prospective Study.

Journal of Alzheimer's disease : JAD

Klöppel S, Peter J, Ludl A, Pilatus A, Maier S, Mader I, Heimbach B, Frings L, Egger K, Dukart J, Schroeter ML, Perneczky R, Häussermann P, Vach W, Urbach H, Teipel S, Hüll M, Abdulkadir A

Common Variants in PLD3 and Correlation to Amyloid-Related Phenotypes in Alzheimer's Disease.

Journal of Alzheimer's disease : JAD

Wang C, Tan L, Wang HF, Yu WJ, Liu Y, Jiang T, Tan MS, Hao XK, Zhang DQ, Yu JT

Identification of Conversion from Normal Elderly Cognition to Alzheimer's Disease using Multimodal Support Vector Machine.

Journal of Alzheimer's disease : JAD

Zhan Y, Chen K, Wu X, Zhang D, Zhang J, Yao L, Guo X

Risk Stratification Using Cerebrospinal Fluid Biomarkers in Patients with Mild Cognitive Impairment: An Exploratory Analysis.

Journal of Alzheimer's disease : JAD

Michaud TL, Kane RL, McCarten JR, Gaugler JE, Nyman JA, Kuntz KM

Study of amyloid-ß peptide functional brain networks in AD, MCI and HC.

Bio-medical materials and engineering

Jiang J, Duan H, Huang Z, Yu Z

Anomalous functional language lateralization in semantic variant PPA.

Neurology

Miller ZA, Hinkley LB, Herman A, Honma S, Findlay A, Block N, Ketelle R, Rabinovici G, Rosen H, Nagarajan SS, Miller BL, Gorno-Tempini ML

Damage to left frontal regulatory circuits produces greater positive emotional reactivity in frontotemporal dementia.

Cortex; a journal devoted to the study of the nervous system and behavior

Sturm VE, Yokoyama JS, Eckart JA, Zakrzewski J, Rosen HJ, Miller BL, Seeley WW, Levenson RW

Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion.

Brain : a journal of neurology

Lee SE, Khazenzon AM, Trujillo AJ, Guo CC, Yokoyama JS, Sha SJ, Takada LT, Karydas AM, Block NR, Coppola G, Pribadi M, Geschwind DH, Rademakers R, Fong JC, Weiner MW, Boxer AL, Kramer JH, Rosen HJ, Miller BL, Seeley WW

The Chinese Verbal Learning Test specifically assesses hippocampal state.

American journal of Alzheimer's disease and other dementias

Tsai RM, Leong JK, Dutt S, Chang CC, Lee AK, Chao SZ, Yokoyama JS, Tse M, Kramer JH, Miller BL, Rosen HJ

Self-awareness in neurodegenerative disease relies on neural structures mediating reward-driven attention.

Brain : a journal of neurology

Shany-Ur T, Lin N, Rosen HJ, Sollberger M, Miller BL, Rankin KP

Anatomical correlates of reward-seeking behaviours in behavioural variant frontotemporal dementia.

Brain : a journal of neurology

Perry DC, Sturm VE, Seeley WW, Miller BL, Kramer JH, Rosen HJ

Application of quantitative DTI metrics in sporadic CJD.

NeuroImage. Clinical

Caverzasi E, Henry RG, Vitali P, Lobach IV, Kornak J, Bastianello S, Dearmond SJ, Miller BL, Rosen HJ, Mandelli ML, Geschwind MD

Depressive symptoms in Chinese-American subjects with cognitive impairment.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Chao SZ, Matthews BR, Yokoyama JS, Lai NB, Ong H, Tse M, Yuan RF, Lin A, Kramer J, Yaffe K, Kornak J, Miller BL, Rosen HJ

MRI markers for mild cognitive impairment: comparisons between white matter integrity and gray matter volume measurements.

PloS one

Zhang Y, Schuff N, Camacho M, Chao LL, Fletcher TP, Yaffe K, Woolley SC, Madison C, Rosen HJ, Miller BL, Weiner MW

Progranulin mutations as risk factors for Alzheimer disease.

JAMA neurology

Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G

TDP-43 frontotemporal lobar degeneration and autoimmune disease.

Journal of neurology, neurosurgery, and psychiatry

Miller ZA, Rankin KP, Graff-Radford NR, Takada LT, Sturm VE, Cleveland CM, Criswell LA, Jaeger PA, Stan T, Heggeli KA, Hsu SC, Karydas A, Khan BK, Grinberg LT, Gorno-Tempini ML, Boxer AL, Rosen HJ, Kramer JH, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Wyss-Coray T, Miller BL

Diverging patterns of amyloid deposition and hypometabolism in clinical variants of probable Alzheimer's disease.

Brain : a journal of neurology

Lehmann M, Ghosh PM, Madison C, Laforce R, Corbetta-Rastelli C, Weiner MW, Greicius MD, Seeley WW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ, Rabinovici GD

MRI signatures of brain macrostructural atrophy and microstructural degradation in frontotemporal lobar degeneration subtypes.

Journal of Alzheimer's disease : JAD

Zhang Y, Tartaglia MC, Schuff N, Chiang GC, Ching C, Rosen HJ, Gorno-Tempini ML, Miller BL, Weiner MW

The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier).

Alzheimer's & dementia : the journal of the Alzheimer's Association

Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL

The frontal-anatomic specificity of design fluency repetitions and their diagnostic relevance for behavioral variant frontotemporal dementia.

Journal of the International Neuropsychological Society : JINS

Possin KL, Chester SK, Laluz V, Bostrom A, Rosen HJ, Miller BL, Kramer JH

Role of right pregenual anterior cingulate cortex in self-conscious emotional reactivity.

Social cognitive and affective neuroscience

Sturm VE, Sollberger M, Seeley WW, Rankin KP, Ascher EA, Rosen HJ, Miller BL, Levenson RW

Trajectories of behavioral disturbance in dementia.

Journal of Alzheimer's disease : JAD

Chow TW, Fridhandler JD, Binns MA, Lee A, Merrilees J, Rosen HJ, Ketelle R, Miller BL

Behaviour, physiology and experience of pathological laughing and crying in amyotrophic lateral sclerosis.

Brain : a journal of neurology

Olney NT, Goodkind MS, Lomen-Hoerth C, Whalen PK, Williamson CA, Holley DE, Verstaen A, Brown LM, Miller BL, Kornak J, Levenson RW, Rosen HJ

Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD.

Neurology

Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, Mormino EC, O'Neil JP, Janabi M, Karydas A, Growdon ME, Jang JY, Huang EJ, Dearmond SJ, Trojanowski JQ, Grinberg LT, Gorno-Tempini ML, Seeley WW, Miller BL, Jagust WJ

Neuroimaging in dementia.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Tartaglia MC, Rosen HJ, Miller BL

Increased metabolic vulnerability in early-onset Alzheimer's disease is not related to amyloid burden.

Brain : a journal of neurology

Rabinovici GD, Furst AJ, Alkalay A, Racine CA, O'Neil JP, Janabi M, Baker SL, Agarwal N, Bonasera SJ, Mormino EC, Weiner MW, Gorno-Tempini ML, Rosen HJ, Miller BL, Jagust WJ

Longitudinal rates of lobar atrophy in frontotemporal dementia, semantic dementia, and Alzheimer's disease.

Alzheimer disease and associated disorders

Krueger CE, Dean DL, Rosen HJ, Halabi C, Weiner M, Miller BL, Kramer JH

Neuroanatomical correlates of cognitive self-appraisal in neurodegenerative disease.

NeuroImage

Rosen HJ, Alcantar O, Rothlind J, Sturm V, Kramer JH, Weiner M, Miller BL

White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI.

Brain : a journal of neurology

Zhang Y, Schuff N, Du AT, Rosen HJ, Kramer JH, Gorno-Tempini ML, Miller BL, Weiner MW

Patterns of structural complexity in Alzheimer's disease and frontotemporal dementia.

Human brain mapping

Young K, Du AT, Kramer J, Rosen H, Miller B, Weiner M, Schuff N

Rule violation errors are associated with right lateral prefrontal cortex atrophy in neurodegenerative disease.

Journal of the International Neuropsychological Society : JINS

Possin KL, Brambati SM, Rosen HJ, Johnson JK, Pa J, Weiner MW, Miller BL, Kramer JH

Correlating DWI MRI with pathologic and other features of Jakob-Creutzfeldt disease.

Alzheimer disease and associated disorders

Geschwind MD, Potter CA, Sattavat M, Garcia PA, Rosen HJ, Miller BL, DeArmond SJ

Neuroimaging in dementia.

Seminars in neurology

Vitali P, Migliaccio R, Agosta F, Rosen HJ, Geschwind MD

Dextromethorphan/quinidine sulfate for pseudobulbar affect.

Drugs of today (Barcelona, Spain : 1998)

Rosen H

Cortical neuroanatomy and cognition.

Handbook of clinical neurology

Rosen HJ, Viskontas IV

Distinct MRI atrophy patterns in autopsy-proven Alzheimer's disease and frontotemporal lobar degeneration.

American journal of Alzheimer's disease and other dementias

Rabinovici GD, Seeley WW, Kim EJ, Gorno-Tempini ML, Rascovsky K, Pagliaro TA, Allison SC, Halabi C, Kramer JH, Johnson JK, Weiner MW, Forman MS, Trojanowski JQ, Dearmond SJ, Miller BL, Rosen HJ

Patterns of white matter atrophy in frontotemporal lobar degeneration.

Archives of neurology

Chao LL, Schuff N, Clevenger EM, Mueller SG, Rosen HJ, Gorno-Tempini ML, Kramer JH, Miller BL, Weiner MW

Atrophy progression in semantic dementia with asymmetric temporal involvement: a tensor-based morphometry study.

Neurobiology of aging

Brambati SM, Rankin KP, Narvid J, Seeley WW, Dean D, Rosen HJ, Miller BL, Ashburner J, Gorno-Tempini ML

Magnetic resonance imaging correlates of set shifting.

Journal of the International Neuropsychological Society : JINS

Kramer JH, Quitania L, Dean D, Neuhaus J, Rosen HJ, Halabi C, Weiner MW, Magnotta VA, Delis DC, Miller BL

11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration.

Neurology

Rabinovici GD, Furst AJ, O'Neil JP, Racine CA, Mormino EC, Baker SL, Chetty S, Patel P, Pagliaro TA, Klunk WE, Mathis CA, Rosen HJ, Miller BL, Jagust WJ

Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia.

Brain : a journal of neurology

Du AT, Schuff N, Kramer JH, Rosen HJ, Gorno-Tempini ML, Rankin K, Miller BL, Weiner MW

A tensor based morphometry study of longitudinal gray matter contraction in FTD.

NeuroImage

Brambati SM, Renda NC, Rankin KP, Rosen HJ, Seeley WW, Ashburner J, Weiner MW, Miller BL, Gorno-Tempini ML

A real reason for patients with pseudobulbar affect to smile.

Annals of neurology

Rosen HJ, Cummings J

Behavioral features in semantic dementia vs other forms of progressive aphasias.

Neurology

Rosen HJ, Allison SC, Ogar JM, Amici S, Rose K, Dronkers N, Miller BL, Gorno-Tempini ML

Hypoperfusion in frontotemporal dementia and Alzheimer disease by arterial spin labeling MRI.

Neurology

Du AT, Jahng GH, Hayasaka S, Kramer JH, Rosen HJ, Gorno-Tempini ML, Rankin KP, Miller BL, Weiner MW, Schuff N

Multiple cognitive deficits in amnestic mild cognitive impairment.

Dementia and geriatric cognitive disorders

Kramer JH, Nelson A, Johnson JK, Yaffe K, Glenn S, Rosen HJ, Miller BL

Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy.

Archives of neurology

Boxer AL, Geschwind MD, Belfor N, Gorno-Tempini ML, Schauer GF, Miller BL, Weiner MW, Rosen HJ

Clinical and neuropsychological features of corticobasal degeneration.

Mechanisms of ageing and development

Belfor N, Amici S, Boxer AL, Kramer JH, Gorno-Tempini ML, Rosen HJ, Miller BL

Dissociations in hippocampal and frontal contributions to episodic memory performance.

Neuropsychology

Kramer JH, Rosen HJ, Du AT, Schuff N, Hollnagel C, Weiner MW, Miller BL, Delis DC

Neuroanatomical correlates of behavioural disorders in dementia.

Brain : a journal of neurology

Rosen HJ, Allison SC, Schauer GF, Gorno-Tempini ML, Weiner MW, Miller BL

Neuroanatomical correlates of impaired recognition of emotion in dementia.

Neuropsychologia

Rosen HJ, Wilson MR, Schauer GF, Allison S, Gorno-Tempini ML, Pace-Savitsky C, Kramer JH, Levenson RW, Weiner M, Miller BL

Frontotemporal lobar degeneration: demographic characteristics of 353 patients.

Archives of neurology

Johnson JK, Diehl J, Mendez MF, Neuhaus J, Shapira JS, Forman M, Chute DJ, Roberson ED, Pace-Savitsky C, Neumann M, Chow TW, Rosen HJ, Forstl H, Kurz A, Miller BL

The natural history of temporal variant frontotemporal dementia.

Neurology

Seeley WW, Bauer AM, Miller BL, Gorno-Tempini ML, Kramer JH, Weiner M, Rosen HJ

Regulation of immunity by lysosphingolipids and their G protein-coupled receptors.

The Journal of clinical investigation

Goetzl EJ, Rosen H

Neuropsychological and functional measures of severity in Alzheimer disease, frontotemporal dementia, and semantic dementia.

Alzheimer disease and associated disorders

Rosen HJ, Narvaez JM, Hallam B, Kramer JH, Wyss-Coray C, Gearhart R, Johnson JK, Miller BL

Cognitive and behavioral profile in a case of right anterior temporal lobe neurodegeneration.

Cortex; a journal devoted to the study of the nervous system and behavior

Gorno-Tempini ML, Rankin KP, Woolley JD, Rosen HJ, Phengrasamy L, Miller BL

Hippocampal volume and retention in Alzheimer's disease.

Journal of the International Neuropsychological Society : JINS

Kramer JH, Schuff N, Reed BR, Mungas D, Du AT, Rosen HJ, Jagust WJ, Miller BL, Weiner MW, Chui HC

Cognition and anatomy in three variants of primary progressive aphasia.

Annals of neurology

Gorno-Tempini ML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, Johnson JK, Weiner MW, Miller BL

Recognition of emotion in the frontal and temporal variants of frontotemporal dementia.

Dementia and geriatric cognitive disorders

Rosen HJ, Pace-Savitsky K, Perry RJ, Kramer JH, Miller BL, Levenson RW

Right and left medial orbitofrontal volumes show an opposite relationship to agreeableness in FTD.

Dementia and geriatric cognitive disorders

Rankin KP, Rosen HJ, Kramer JH, Schauer GF, Weiner MW, Schuff N, Miller BL

Focal right inferotemporal atrophy in AD with disproportionate visual constructive impairment.

Neurology

Boxer AL, Kramer JH, Du AT, Schuff N, Weiner MW, Miller BL, Rosen HJ

Distinctive neuropsychological patterns in frontotemporal dementia, semantic dementia, and Alzheimer disease.

Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology

Kramer JH, Jurik J, Sha SJ, Rankin KP, Rosen HJ, Johnson JK, Miller BL

Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementia.

Archives of neurology

Boxer AL, Rankin KP, Miller BL, Schuff N, Weiner M, Gorno-Tempini ML, Rosen HJ

Emotion comprehension in the temporal variant of frontotemporal dementia.

Brain : a journal of neurology

Rosen HJ, Perry RJ, Murphy J, Kramer JH, Mychack P, Schuff N, Weiner M, Levenson RW, Miller BL

Utility of clinical criteria in differentiating frontotemporal lobar degeneration (FTLD) from AD.

Neurology

Rosen HJ, Hartikainen KM, Jagust W, Kramer JH, Reed BR, Cummings JL, Boone K, Ellis W, Miller C, Miller BL

Patterns of brain atrophy in frontotemporal dementia and semantic dementia.

Neurology

Rosen HJ, Gorno-Tempini ML, Goldman WP, Perry RJ, Schuff N, Weiner M, Feiwell R, Kramer JH, Miller BL

Patterns of cerebral atrophy in primary progressive aphasia.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Rosen HJ, Kramer JH, Gorno-Tempini ML, Schuff N, Weiner M, Miller BL

Neuroanatomy of the self: evidence from patients with frontotemporal dementia.

Neurology

Miller BL, Seeley WW, Mychack P, Rosen HJ, Mena I, Boone K