Malu Mandelli, PhD

Assistant Professional Researcher
+1 415 476-3861
Fields of Interest: 

Maria Luisa Mandelli leads the neuroimaging research within the language team of the Memory and Aging Center. Her research focuses on neuroanatomical changes caused by language and other neurodegenerative disorders. She has been working on brain magnetic resonance imaging for the past ten years, with the goal of better understanding of how the brain develops, changes over time, and how it makes us who we are.

She completed a PhD degree in biomedical engineering in Italy at the Politecnico di Milano in collaboration with Neurological Institute C. Besta. Maria Luisa joined UCSF in 2010, specializing in brain imaging processing.

Publications: 

Functional and morphological correlates of developmental dyslexia: A multimodal investigation of the ventral occipitotemporal cortex.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

Borghesani V, Wang C, Watson C, Bouhali F, Caverzasi E, Battistella G, Bogley R, Yabut NA, Deleon J, Miller ZA, Hoeft F, Mandelli ML, Gorno-Tempini ML

Cortically constrained shape recognition: Automated white matter tract segmentation validated in the pediatric brain.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

Enhanced visceromotor emotional reactivity in dyslexia and its relation to salience network connectivity.

Cortex; a journal devoted to the study of the nervous system and behavior

Sturm VE, Roy ARK, Datta S, Wang C, Sible IJ, Holley SR, Watson C, Palser ER, Morris NA, Battistella G, Rah E, Meyer M, Pakvasa M, Mandelli ML, Deleon J, Hoeft F, Caverzasi E, Miller ZA, Shapiro KA, Hendren R, Miller BL, Gorno-Tempini ML

Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology.

NeuroImage. Clinical

Borghesani V, Battistella G, Mandelli ML, Welch A, Weis E, Younes K, Neuhaus J, Grinberg LT, Seeley WM, Spina S, Miller B, Miller Z, Gorno-Tempini ML

MRI Measurement of Upper Cervical Spinal Cord Cross-Sectional Area in Children.

Journal of neuroimaging : official journal of the American Society of Neuroimaging

Papinutto N, Cordano C, Asteggiano C, Caverzasi E, Mandelli ML, Lauricella M, Yabut N, Neylan M, Kirkish G, Gorno-Tempini ML, Henry RG

Speech production differences in English and Italian speakers with nonfluent variant PPA.

Neurology

Canu E, Agosta F, Battistella G, Spinelli EG, DeLeon J, Welch AE, Mandelli ML, Hubbard HI, Moro A, Magnani G, Cappa SF, Miller BL, Filippi M, Gorno-Tempini ML

Task-Free Functional Language Networks: Reproducibility and Clinical Application.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Battistella G, Borghesani V, Henry M, Shwe W, Lauricella M, Miller Z, Deleon J, Miller BL, Dronkers N, Brambati SM, Seeley WW, Mandelli ML, Gorno-Tempini ML

Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia.

Brain Communications

Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML

Neurocognitive basis of repetition deficits in primary progressive aphasia.

Brain and language

Lukic S, Mandelli ML, Welch A, Jordan K, Shwe W, Neuhaus J, Miller Z, Hubbard HI, Henry M, Miller BL, Dronkers NF, Gorno-Tempini ML

Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia.

Neurocase

De Leon J, Mandelli ML, Nolan A, Miller ZA, Mead C, Watson C, Welch AE, Henry ML, Bourakova V, La Joie R, Bajorek LP, Grinberg L, Rabinovici G, Miller BL, Gorno-Tempini ML

Differential intrinsic functional connectivity changes in semantic variant primary progressive aphasia.

NeuroImage. Clinical

Battistella G, Henry M, Gesierich B, Wilson SM, Borghesani V, Shwe W, Miller Z, Deleon J, Miller BL, Jovicich J, Papinutto N, Dronkers NF, Seeley WW, Mandelli ML, Gorno-Tempini ML

"Looks familiar, but I do not know who she is": The role of the anterior right temporal lobe in famous face recognition.

Cortex; a journal devoted to the study of the nervous system and behavior

Borghesani V, Narvid J, Battistella G, Shwe W, Watson C, Binney RJ, Sturm V, Miller Z, Mandelli ML, Miller B, Gorno-Tempini ML

Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates.

Amyotrophic lateral sclerosis & frontotemporal degeneration

Vinceti G, Olney N, Mandelli ML, Spina S, Hubbard HI, Santos-Santos MA, Watson C, Miller ZA, Lomen-Hoerth C, Nichelli P, Miller BL, Grinberg LT, Seeley WW, Gorno-Tempini ML

Altered topology of the functional speech production network in non-fluent/agrammatic variant of PPA.

Cortex; a journal devoted to the study of the nervous system and behavior

Mandelli ML, Welch AE, Vilaplana E, Watson C, Battistella G, Brown JA, Possin KL, Hubbard HI, Miller ZA, Henry ML, Marx GA, Santos-Santos MA, Bajorek LP, Fortea J, Boxer A, Rabinovici G, Lee S, Deleon J, Rosen HJ, Miller BL, Seeley WW, Gorno-Tempini ML

Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy.

JAMA neurology

Miller ZA, Rosenberg L, Santos-Santos MA, Stephens M, Allen IE, Hubbard HI, Cantwell A, Mandelli ML, Grinberg LT, Seeley WW, Miller BL, Rabinovici GD, Gorno-Tempini ML

Retraining speech production and fluency in non-fluent/agrammatic primary progressive aphasia.

Brain : a journal of neurology

Henry ML, Hubbard HI, Grasso SM, Mandelli ML, Wilson SM, Sathishkumar MT, Fridriksson J, Daigle W, Boxer AL, Miller BL, Gorno-Tempini ML

Abnormal age-related cortical folding and neurite morphology in children with developmental dyslexia.

NeuroImage. Clinical

Caverzasi E, Mandelli ML, Hoeft F, Watson C, Meyer M, Allen IE, Papinutto N, Wang C, Gandini Wheeler-Kingshott CAM, Marco EJ, Mukherjee P, Miller ZA, Miller BL, Hendren R, Shapiro KA, Gorno-Tempini ML

Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia.

JAMA neurology

Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML

Distinct spatiotemporal patterns of neuronal functional connectivity in primary progressive aphasia variants.

Brain : a journal of neurology

Ranasinghe KG, Hinkley LB, Beagle AJ, Mizuiri D, Honma SM, Welch AE, Hubbard I, Mandelli ML, Miller ZA, Garrett C, La A, Boxer AL, Houde JF, Miller BL, Vossel KA, Gorno-Tempini ML, Nagarajan SS

Early changes in brain structure correlate with language outcomes in children with neonatal encephalopathy.

NeuroImage. Clinical

Shapiro KA, Kim H, Mandelli ML, Rogers EE, Gano D, Ferriero DM, Barkovich AJ, Gorno-Tempini ML, Glass HC, Xu D

Typical and atypical pathology in primary progressive aphasia variants.

Annals of neurology

Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, Miller BL, Seeley WW, Gorno-Tempini ML

Focal temporal pole atrophy and network degeneration in semantic variant primary progressive aphasia.

Brain : a journal of neurology

Collins JA, Montal V, Hochberg D, Quimby M, Mandelli ML, Makris N, Seeley WW, Gorno-Tempini ML, Dickerson BC

Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers.

NeuroImage. Clinical

Lee SE, Sias AC, Mandelli ML, Brown JA, Brown AB, Khazenzon AM, Vidovszky AA, Zanto TP, Karydas AM, Pribadi M, Dokuru D, Coppola G, Geschwind DH, Rademakers R, Gorno-Tempini ML, Rosen HJ, Miller BL, Seeley WW

Healthy brain connectivity predicts atrophy progression in non-fluent variant of primary progressive aphasia.

Brain : a journal of neurology

Mandelli ML, Vilaplana E, Brown JA, Hubbard HI, Binney RJ, Attygalle S, Santos-Santos MA, Miller ZA, Pakvasa M, Henry ML, Rosen HJ, Henry RG, Rabinovici GD, Miller BL, Seeley WW, Gorno-Tempini ML

Reading words and other people: A comparison of exception word, familiar face and affect processing in the left and right temporal variants of primary progressive aphasia.

Cortex; a journal devoted to the study of the nervous system and behavior

Binney RJ, Henry ML, Babiak M, Pressman PS, Santos-Santos MA, Narvid J, Mandelli ML, Strain PJ, Miller BL, Rankin KP, Rosen HJ, Gorno-Tempini ML

Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration.

JAMA neurology

Santos-Santos MA, Mandelli ML, Binney RJ, Ogar J, Wilson SM, Henry ML, Hubbard HI, Meese M, Attygalle S, Rosenberg L, Pakvasa M, Trojanowski JQ, Grinberg LT, Rosen H, Boxer AL, Miller BL, Seeley WW, Gorno-Tempini ML

Structural connectivity of the human anterior temporal lobe: A diffusion magnetic resonance imaging study.

Human brain mapping

Papinutto N, Galantucci S, Mandelli ML, Gesierich B, Jovicich J, Caverzasi E, Henry RG, Seeley WW, Miller BL, Shapiro KA, Gorno-Tempini ML

Two insular regions are differentially involved in behavioral variant FTD and nonfluent/agrammatic variant PPA.

Cortex; a journal devoted to the study of the nervous system and behavior

Mandelli ML, Vitali P, Santos M, Henry M, Gola K, Rosenberg L, Dronkers N, Miller B, Seeley WW, Gorno-Tempini ML

Phonological Processing in Primary Progressive Aphasia.

Journal of cognitive neuroscience

Henry ML, Wilson SM, Babiak MC, Mandelli ML, Beeson PM, Miller ZA, Gorno-Tempini ML

White matter involvement in sporadic Creutzfeldt-Jakob disease.

Brain : a journal of neurology

Caverzasi E, Mandelli ML, DeArmond SJ, Hess CP, Vitali P, Papinutto N, Oehler A, Miller BL, Lobach IV, Bastianello S, Geschwind MD, Henry RG

Frontal white matter tracts sustaining speech production in primary progressive aphasia.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Mandelli ML, Caverzasi E, Binney RJ, Henry ML, Lobach I, Block N, Amirbekian B, Dronkers N, Miller BL, Henry RG, Gorno-Tempini ML

Quantifying accuracy and precision of diffusion MR tractography of the corticospinal tract in brain tumors.

Journal of neurosurgery

Mandelli ML, Berger MS, Bucci M, Berman JI, Amirbekian B, Henry RG

Frontal cortex BOLD signal changes in premanifest Huntington disease: a possible fMRI biomarker.

Neurology

Ferraro S, Nanetti L, Piacentini S, Mandelli ML, Bertolino N, Ghielmetti F, Epifani F, Nigri A, Taroni F, Bruzzone MG, Di Donato S, Savoiardo M, Mariotti C, Grisoli M

Application of quantitative DTI metrics in sporadic CJD.

NeuroImage. Clinical

Caverzasi E, Henry RG, Vitali P, Lobach IV, Kornak J, Bastianello S, Dearmond SJ, Miller BL, Rosen HJ, Mandelli ML, Geschwind MD

In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology.

Neurology

Caso F, Mandelli ML, Henry M, Gesierich B, Bettcher BM, Ogar J, Filippi M, Comi G, Magnani G, Sidhu M, Trojanowski JQ, Huang EJ, Grinberg LT, Miller BL, Dronkers N, Seeley WW, Gorno-Tempini ML

What role does the anterior temporal lobe play in sentence-level processing? Neural correlates of syntactic processing in semantic variant primary progressive aphasia.

Journal of cognitive neuroscience

Wilson SM, DeMarco AT, Henry ML, Gesierich B, Babiak M, Mandelli ML, Miller BL, Gorno-Tempini ML

Handedness and language learning disability differentially distribute in progressive aphasia variants.

Brain : a journal of neurology

Miller ZA, Mandelli ML, Rankin KP, Henry ML, Babiak MC, Frazier DT, Lobach IV, Bettcher BM, Wu TQ, Rabinovici GD, Graff-Radford NR, Miller BL, Gorno-Tempini ML

Quantifying diffusion MRI tractography of the corticospinal tract in brain tumors with deterministic and probabilistic methods.

NeuroImage. Clinical

Bucci M, Mandelli ML, Berman JI, Amirbekian B, Nguyen C, Berger MS, Henry RG

In medication-overuse headache, fMRI shows long-lasting dysfunction in midbrain areas.

Headache

Ferraro S, Grazzi L, Muffatti R, Nava S, Ghielmetti F, Bertolino N, Mandelli ML, Visintin E, Bruzzone MG, Nigri A, Epifani F, Bussone G, Chiapparini L

Neural stem cell engraftment and myelination in the human brain.

Science translational medicine

Gupta N, Henry RG, Strober J, Kang SM, Lim DA, Bucci M, Caverzasi E, Gaetano L, Mandelli ML, Ryan T, Perry R, Farrell J, Jeremy RJ, Ulman M, Huhn SL, Barkovich AJ, Rowitch DH

Pain processing in medication overuse headache: a functional magnetic resonance imaging (fMRI) study.

Pain medicine (Malden, Mass.)

Ferraro S, Grazzi L, Mandelli ML, Aquino D, Di Fiore D, Usai S, Bruzzone MG, Di Salle F, Bussone G, Chiapparini L

Chronic migraine with medication overuse pre-post withdrawal of symptomatic medication: clinical results and FMRI correlations.

Headache

Grazzi L, Chiapparini L, Ferraro S, Usai S, Andrasik F, Mandelli ML, Bruzzone MG, Bussone G

Decreased diffusivity in the caudate nucleus of presymptomatic huntington disease gene carriers: which explanation?

AJNR. American journal of neuroradiology

Mandelli ML, Savoiardo M, Minati L, Mariotti C, Aquino D, Erbetta A, Genitrini S, Di Donato S, Bruzzone MG, Grisoli M

Diffusion tensor imaging shows different topographic involvement of the thalamus in progressive supranuclear palsy and corticobasal degeneration.

AJNR. American journal of neuroradiology

Erbetta A, Mandelli ML, Savoiardo M, Grisoli M, Bizzi A, Soliveri P, Chiapparini L, Prioni S, Bruzzone MG, Girotti F

Functional-MRI evaluation of pain processing in chronic migraine with medication overuse.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Chiapparini L, Grazzi L, Ferraro S, Mandelli ML, Usai S, Andrasik F, Bruzzone MG, Bussone G

Plasma 24S-hydroxycholesterol and caudate MRI in pre-manifest and early Huntington's disease.

Brain : a journal of neurology

Leoni V, Mariotti C, Tabrizi SJ, Valenza M, Wild EJ, Henley SM, Hobbs NZ, Mandelli ML, Grisoli M, Björkhem I, Cattaneo E, Di Donato S

Elevating tensor rank increases anisotropy in brain areas associated with intra-voxel orientational heterogeneity (IVOH): a generalised DTI (GDTI) study.

NMR in biomedicine

Minati L, Banasik T, Brzezinski J, Mandelli ML, Bizzi A, Bruzzone MG, Konopka M, Jasinski A

Diffusion tensor imaging of spinocerebellar ataxias types 1 and 2.

AJNR. American journal of neuroradiology

Mandelli ML, De Simone T, Minati L, Bruzzone MG, Mariotti C, Fancellu R, Savoiardo M, Grisoli M

Dural sinus thrombosis in spontaneous intracranial hypotension: Hypotheses on possible mechanisms.

Journal of neurology

Savoiardo M, Armenise S, Spagnolo P, De Simone T, Mandelli ML, Marcone A, Morciano G, Andreula C, Mea E, Leone M, Chiapparini L

Pharmacokinetics and tolerance of a new penem antibiotic, FCE 22101, in healthy volunteers after a single intravenous dose.

European journal of clinical pharmacology

Jannuzzo MG, Mandelli M, Benedetti MS, Moro E, Carnovali M, Vaiani R, Sassella D

Clinical pharmacokinetics of diazepam.

Clinical pharmacokinetics

Mandelli M, Tognoni G, Garattini S