Adam Staffaroni, PhD

Assistant Professor
Neurology
Fields of Interest: 

Dr. Staffaroni is neuropsychologist in the UCSF Department of Neurology. He provides clinical neuropsychological assessments, and his research focuses on predicting disease progression and improving endpoints for clinical trials in neurodegenerative diseases. He completed a MS degree and PhD in Clinical Psychology at Palo Alto University, with an emphasis in neuropsychology. His training included a clinical internship at the West Los Angeles VA Health Care system, where he also studied FDG-PET correlates of memory in Alzheimer’s disease. He then completed a two-year postdoctoral fellowship in neuropsychology at the UCSF Memory and Aging Center (MAC).

In his work at the MAC, his research program aims to prepare for clinical trials in neurodegenerative diseases by: 1) developing and validating trial endpoints, 2) leveraging multimodal neuroimaging and fluid biomarkers to predict patients’ clinical course and inform clinical trial stratification, and 3) developing novel approaches for selecting clinical trial endpoints that account for disease heterogeneity. He is also interested in healthy aging and studies the aging brain through a combination of functional connectivity, structural imaging, and perfusion imaging.

Publications: 

Assessment of executive function declines in presymptomatic and mildly symptomatic familial frontotemporal dementia: NIH-EXAMINER as a potential clinical trial endpoint.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Staffaroni AM, Bajorek L, Casaletto KB, Cobigo Y, Goh SM, Wolf A, Heuer HW, Elahi FM, Ljubenkov PA, Dever R, Kornak J, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber D, Caso C, Coppola G, Dheel C, Dickerson BC, Dickinson S, Dominguez S, Domoto-Reilly K, Faber K, Ferrall J, Fields JA, Fishman A, Fong J, Foroud T, Forsberg LK, Gavrilova R, Gearhart D, Ghazanfari B, Ghoshal N, Goldman J, Graff-Radford J, Graff-Radford N, Grant I, Grossman M, Haley D, Hsiung GY, Huey ED, Irwin DJ, Jones DT, Jones L, Kantarci K, Karydas A, Kaufer DI, Kerwin DR, Knopman DS, Kraft R, Kremers WK, Kukull WA, Litvan I, Lucente D, Lungu C, Mackenzie IR, Maldonado M, Manoochehri M, McGinnis SM, McKinley E, Mendez MF, Miller BL, Multani N, Onyike C, Padmanabhan J, Pantelyat A, Pearlman R, Petrucelli L, Potter M, Rademakers R, Ramos EM, Rankin KP, Rascovsky K, Roberson ED, Rogalski E, Sengdy P, Shaw LM, Syrjanen J, Tartaglia MC, Tatton N, Taylor J, Toga A, Trojanowski JQ, Weintraub S, Wang P, Wong B, Wszolek Z, Boxer AL, Boeve BF, Kramer JH, Rosen HJ

A longitudinal characterization of perfusion in the aging brain and associations with cognition and neural structure.

Human brain mapping

Staffaroni AM, Cobigo Y, Elahi FM, Casaletto KB, Walters SM, Wolf A, Lindbergh CA, Rosen HJ, Kramer JH

Association of Blood and Cerebrospinal Fluid Tau Level and Other Biomarkers With Survival Time in Sporadic Creutzfeldt-Jakob Disease.

JAMA neurology

Staffaroni AM, Kramer AO, Casey M, Kang H, Rojas JC, Orrú CD, Caughey B, Allen IE, Kramer JH, Rosen HJ, Blennow K, Zetterberg H, Geschwind MD

Efficacy of Mindfulness-Based Cognitive Training in Surgery: Additional Analysis of the Mindful Surgeon Pilot Randomized Clinical Trial.

JAMA network open

Lebares CC, Guvva EV, Olaru M, Sugrue LP, Staffaroni AM, Delucchi KL, Kramer JH, Ascher NL, Harris HW

Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials.

Brain : a journal of neurology

Staffaroni AM, Ljubenkov PA, Kornak J, Cobigo Y, Datta S, Marx G, Walters SM, Chiang K, Olney N, Elahi FM, Knopman DS, Dickerson BC, Boeve BF, Gorno-Tempini ML, Spina S, Grinberg LT, Seeley WW, Miller BL, Kramer JH, Boxer AL, Rosen HJ

Cognitive aging is not created equally: differentiating unique cognitive phenotypes in "normal" adults.

Neurobiology of aging

Casaletto KB, Elahi FM, Staffaroni AM, Walters S, Contreras WR, Wolf A, Dubal D, Miller B, Yaffe K, Kramer JH

Primary School Education May Be Sufficient to Moderate a Memory-Hippocampal Relationship.

Frontiers in aging neuroscience

Resende EPF, Rosen HJ, Chiang K, Staffaroni AM, Allen I, Grinberg LT, Carmona KC, Guimarães HC, Carvalho VA, Barbosa MT, de Souza LC, Caramelli P

"Liquid Biopsy" of White Matter Hyperintensity in Functionally Normal Elders.

Frontiers in aging neuroscience

Elahi FM, Casaletto KB, Altendahl M, Staffaroni AM, Fletcher E, Filshtein TJ, Glymour MM, Miller BL, Hinman JD, DeCarli C, Goetzl EJ, Kramer JH

Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory.

Annals of clinical and translational neurology

Ljubenkov PA, Staffaroni AM, Rojas JC, Allen IE, Wang P, Heuer H, Karydas A, Kornak J, Cobigo Y, Seeley WW, Grinberg LT, Spina S, Fagan AM, Jerome G, Knopman D, Boeve BF, Dickerson BC, Kramer J, Miller B, Boxer AL, Rosen HJ

Perceived Stress is Associated with Accelerated Monocyte/Macrophage Aging Trajectories in Clinically Normal Adults.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Casaletto KB, Staffaroni AM, Elahi F, Fox E, Crittenden PA, You M, Neuhaus J, Glymour M, Bettcher BM, Yaffe K, Kramer JH

A comparison of biofluid cytokine markers across platform technologies: Correspondence or divergence?

Cytokine

Casaletto KB, Elahi FE, Fitch R, Walters S, Fox E, Staffaroni AM, Bettcher B, Zetterberg H, Karydas A, Rojas JC, Boxer AL, Kramer JH

Telomere attrition is associated with declines in medial temporal lobe volume and white matter microstructure in functionally independent older adults.

Neurobiology of aging

Staffaroni AM, Tosun D, Lin J, Elahi FM, Casaletto KB, Wynn MJ, Patel N, Neuhaus J, Walters SM, Epel ES, Blackburn EH, Kramer JH

The Longitudinal Trajectory of Default Mode Network Connectivity in Healthy Older Adults Varies As a Function of Age and Is Associated with Changes in Episodic Memory and Processing Speed.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Staffaroni AM, Brown JA, Casaletto KB, Elahi FM, Deng J, Neuhaus J, Cobigo Y, Mumford PS, Walters S, Saloner R, Karydas A, Coppola G, Rosen HJ, Miller BL, Seeley WW, Kramer JH

Neuroimaging in Dementia.

Seminars in neurology

Staffaroni AM, Elahi FM, McDermott D, Marton K, Karageorgiou E, Sacco S, Paoletti M, Caverzasi E, Hess CP, Rosen HJ, Geschwind MD

Longitudinal white matter change in frontotemporal dementia subtypes and sporadic late onset Alzheimer's disease.

NeuroImage. Clinical

Elahi FM, Marx G, Cobigo Y, Staffaroni AM, Kornak J, Tosun D, Boxer AL, Kramer JH, Miller BL, Rosen HJ

Data-driven regions of interest for longitudinal change in three variants of frontotemporal lobar degeneration.

Brain and behavior

Binney RJ, Pankov A, Marx G, He X, McKenna F, Staffaroni AM, Kornak J, Attygalle S, Boxer AL, Schuff N, Gorno-Tempini ML, Weiner MW, Kramer JH, Miller BL, Rosen HJ

The functional neuroanatomy of verbal memory in Alzheimer's disease: [18F]-Fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) correlates of recency and recognition memory.

Journal of clinical and experimental neuropsychology

Staffaroni AM, Melrose RJ, Leskin LP, Riskin-Jones H, Harwood D, Mandelkern M, Sultzer DL

Data-driven regions of interest for longitudinal change in frontotemporal lobar degeneration.

NeuroImage. Clinical

Pankov A, Binney RJ, Staffaroni AM, Kornak J, Attygalle S, Schuff N, Weiner MW, Kramer JH, Dickerson BC, Miller BL, Rosen HJ

CapMan: independent investigation of capacity and manipulation with a new working memory paradigm.

Brain imaging and behavior

Dobryakova E, Staffaroni A, DeLuca J, Sumowski JF, Chiaravalloti N, Wylie GR